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ADS1299: Bias,Reference and Ground

Part Number: ADS1299
Other Parts Discussed in Thread: ADS1294R, ADS1298,

Hi

I am using the ADS1299 for an EEG application, I'm going to design a 16 channels single ended EEG system. I have the EVM board and checked whole ADS1299 datasheet and the EVM board Guide, and also some questions in forum. But yet, I have problem with something.

1- what should I do about my reference? as I read, i should turn on SRB1 in MISC1 register and simultaneously link the SRB1 pin to the reference electrode. is it correct?

2-  I understand that I have to link just some of the BIAS_SENSs to the BIASINV to prevent saturating the channel. the problem is about the Bias signal, should I link BIASOUT and BIASIN pins? if we don't link them, where should PINOUT go and if link them, with respect to the below image the SRB and BIASIN pins are connected, what does it mean? and another thing that what is the effect of putting MUX[2:0] in 110 or 111 position? 

3- the last question is about the grounds. is it a relation between our reference and Bias and grounds? what should I do about my analog and digital grounds and how should I link them?

4- for this system, is there any pros for each one of daisy chain or cascade connection of 2 ads1299 s with eachother?

5- is there any important difference between connecting device to unipolar or bipolar supplies for this system?

Thanks