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TUSB2046I: Unable to get an output from USB Hub

Part Number: TUSB2046I

Hi,

I have trouble getting an output from the USB Hub to the usb-to-serial IC chip FT232RL.

The host computer is able to detect the USB Hub and the FT232RL chip separately, however there lacks an output from the Hub.

I have attached the USB Hub schematic.

Regards,

Alex