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TPD4E001: can IO1&IO4 / IO2&IO3 connect together ?

Part Number: TPD4E001
Other Parts Discussed in Thread: TPD2E001

Hi Team,

I am finding a part can P2P replace USBLC6-2.https://www.st.com/resource/en/datasheet/usblc6-2.pdf

I found that we have TPD4E001 is pin to pin with it, but we are 4 Channel instead if two, so I'm asking this question : can IO1&IO4 / IO2&IO3 connect together and provide the same protection function ?

I know we have two channel TPD2E001 which have the same functional with USBLC6-2, but it is not P2P.

BR,

Kai