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TCA6408A-Q1: GPIO pin can be used as INT

Part Number: TCA6408A-Q1

I have some concern regarding with i/o Expander TCA6408AQPWRQ1 INT Pin.

Now, I want to add above 2 Switch on GPIO as input with this Expander IC and connect it with this Deserializer. for same i have some questions.

Q1. At which condition of this IC, INT pin will be toggle ?? 

Q2. Can we use this IC's GPIO (P0-P7) pin just like as Interrupt Pin (without polling method)??