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LSF0108-Q1: Can I consider as an impedance of a transmission line?

Part Number: LSF0108-Q1
Other Parts Discussed in Thread: TXU0304-Q1

Hi, how should I consider this components in the transmission line?
I have an IC with series resistor and controlled 50ohms trace, then this shift level LSF0108-Q1 and the trace to the microcontroller.

Should I consider the On-state resistance as a series resistor on the transmission line? Or I need to consider this IC as a new driver with On-state resistance as output impedance and then place the series resistor termination?

Thank you.