I learned that SN74HC240ANS is EOL.
Is SN74HC240ANSR a good replacement?
Also, could you please tell me the meaning of A and R in the model number?
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The SN74HC240NSR identical.
The A has no meaning; see [FAQ] What is the difference between the SN74HCxx and the SN74HCxxA?
The R indicates that the chips are packaged on a reel; no suffix would indicate a tube.