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LM3478Q-Q1: High voltage DCDC converter with LM3478Q-Q1

Part Number: LM3478Q-Q1

I want to make high voltage dc/dc converter without transformer. 

and the voltage would be up to 400V, but the maximum load current is under 10mA.

I will use the typical schematic from the datasheet(as below).

of cause I'll change the FET for high Vds 

Is there any problem or limitation for this idea?

any advice, I'll be happy.