Tool/software: WEBENCH® Design Tools
Starting with the default TPS53219A design with Vin=4.75 to 5.25, Iout=25A, 650kHz, 0.7ms SS time, High ESR + No Ripple Circuit design, I changed the output capacitors from 2 220uF 6SVPE220MW Panasonic capacitors to 1 330uF EEFSX0D331R Panasonic capacitor and the load transient simulation did not change. Once the simulation is completed it displays the circuit with the 2 capacitors rather than the 1 capacitor.
This make evaluating different components impossible but that is a necessary function to determine the best solution.