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SN65LVPE501: Using two SN65LVPE501 on a PCIe Gen 2 x2 interface

Part Number: SN65LVPE501
Other Parts Discussed in Thread: DS50PCI401, DS50PCI402, DS80PCI102, DS160PR410, DS125BR111

I'm interested in using two SN65LVPE501 devices on a PCIe Gen2 x2 interface.  Is there any reason not to do this?  From a lane routing perspective, using these two ICs offers a cleaner route than using a single x4 device such as the DS160PR140 which has all of the PCIe lane inputs on one side of the IC and all of the PCIe lane outputs on the other.  The single x4 interface IC cause two of the lanes to be routed around to the far side of the IC.  Using two SN65LVPE501 allows for a more straight-through routing for all of the lanes.