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TCA6424A interrupt function

Other Parts Discussed in Thread: TCA6424A, TCA9535, TCA9539

Dear Sir 

When I program TCA6424A's GPIO to GPI

if GPI level change (ex . From high to Low)  ,may I use Interrput to indicate??

I would like to do if any GPI level change ,the interrput will alert CPU

Could TCA6424A do it ?? if not ,does TI have any IO expander can do ??

Thanks