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SN54SC6T17-SEP: Is It Suitable for Cold Sparing?

Part Number: SN54SC6T17-SEP

Hello,

Are there any adverse effects if I disable VCC to the SN54SC6T17-SEP while its inputs are still being driven from, e.g., an FPGA?  Is there a difference if I just leave VCC open vs. tying VCC to ground?

Thanks,

Rob