Hi,
as title described, and please see the picture as below:
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Hi Yuan,
This may be possible but we cannot guarantee the device behavior when operated in this way since it has not been fully tested. I spoke with a member of the design team and there are some concerns, especially with the common-mode output voltage. If you look at the device datasheet, you will see that the common-mode output voltage is typically 1.29V, but has a minimum of 1.15V and maximum of 1.45V. Any variation in common-mode output voltage would result in a direct offset error if sensing in a single-ended manner.
To summarize, operating the device from unipolar supplies is best and using an operational amplifier for level shifting and differential to single-ended conversions is best.
Please let me know if you have additional questions.